Genotoxicity of Silver Nanoparticles
نویسندگان
چکیده
منابع مشابه
Appropriate In Vitro Methods for Genotoxicity Testing of Silver Nanoparticles
OBJECTIVES We investigated the genotoxic effects of 40-59 nm silver nanoparticles (Ag-NPs) by bacterial reverse mutation assay (Ames test), in vitro comet assay and micronucleus (MN) assay. In particular, we directly compared the effect of cytochalasin B (cytoB) and rat liver homogenate (S9 mix) in the formation of MN by Ag-NPs. METHODS Before testing, we confirmed that Ag-NPs were completely...
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The focus of this research was to develop a better understanding of the pertinent physico-chemical properties of silver nanoparticles (AgNPs) that affect genotoxicity, specifically how cellular uptake influences a genotoxic cell response. The genotoxicity of AgNPs was assessed for three potential mechanisms: mutagenicity, clastogenicity and DNA strand-break-based DNA damage. Mutagenicity (rever...
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Particles with sizes between 1 and 100nm are termed as nanoparticles and are used commercially across several industrial processes. Since last four decades, different varieties of nanostructures are produced and among them the market potential of AgNPs is predicted to rise from recent 0.79 billion to $2.54 billion by 2022 [1]. Different mode of applications of AgNPs makes them bioavailable in t...
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OBJECTIVES The antimicrobial activity of silver nanoparticles has resulted in their widespread use in many consumer products. Yet, despite their many advantages, it is also important to determine whether silver nanoparticles may represent a hazard to the environment and human health. METHODS Thus, to evaluate the genotoxic potential of silver nanoparticles, in vivo genotoxicity testing (OECD ...
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The use of silver nanoparticles (AgNPs) in commercial products has increased significantly in recent years. Although there have been some attempts to determine the toxic effects of AgNPs in mammalian and human cell-lines, there is little information on plants which play a vital role in ecosystems. The study reports the use of Vicia faba root-tip meristem to investigate the genotoxicity of AgNPs...
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ژورنال
عنوان ژورنال: Nanomaterials
سال: 2020
ISSN: 2079-4991
DOI: 10.3390/nano10020251